Effects of Endogenous Opioids on Pain Mechanism

Pain is defined as an unpleasant sensory and emotional experience, associated with potential tissue damage. Many studies have been conducted to reveal the effects of opioids on pain mechanism. These focused primarily opioid peptides receptor agonists. In general, it declared that dopaminergic, serotonergic, glutaminergic systems well system are closely pain. Morphine, type obtained from Papaver somniferum, has used for relief many years. Morphine other exogenous show their activity by binding receptors in living organisms. respond expressed inactive polypeptide hormones activated proteolytic cleavage. found organisms referred endogenous opioids. Endogenous throughout peripheral central nervous regulate different functions. One main functions peptide modulate our response through a descending modifying pathway. light this data, mechanism elucidated studying review, after definition pain, will be mentioned, methodology recent findings research explained.